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SFPQ antibody

CAT: 0710-FNab07785Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07785Size:100 µg
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Background
SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. This antibody is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.
Synonyms
Splicing factor, proline- and glutamine-rich|100 kDa DNA-pairing protein (hPOMp100) |DNA-binding p52/p100 complex, 100 kDa subunit|Polypyrimidine tract-binding protein-associated-splicing factor (PSF, PTB-associated-splicing factor) |SFPQ|PSF
Gene ID
6421
UniProt
P23246
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)
Target
SFPQ
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:1000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
115 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · P23246

Splicing factor, proline- and glutamine-rich

SFPQ_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23246
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SFPQ
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
P30808, Q5SZ71
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingRepressorRNA-binding

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

Biological rhythmsDNA damageDNA recombinationDNA repairImmunityInnate immunitymRNA processingmRNA splicingTranscriptionTranscription regulation

Domain

Coiled coilRepeat

Cellular component

CytoplasmNucleus

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