SART3 antibody

U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085) . Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385) . May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234) . May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689) . May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity) .

Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) |Tat-interacting protein of 110 kDa (Tip110) |p110 nuclear RNA-binding protein|SART3|KIAA0156|TIP110

9733

Q15020

Human, Mouse, Rat

Squamous cell carcinoma antigen recognized by T cells 3

SART3

ELISA, WB, IHC, IP

Metabolism

Immunogen affinity purified

WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

110 kDa

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)