SAP18 antibody

• Background:

  Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.

• Synonyms:

  Histone deacetylase complex subunit SAP18|18 kDa Sin3-associated polypeptide|2HOR0202|Cell growth-inhibiting gene 38 protein|Sin3-associated polypeptide p18|SAP18

• Gene ID:

  10284

• UniProt:

  O00422

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Sin3A-associated protein, 18kDa

• Target:

  SAP18

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Neuroscience, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200 - 1:2000; IHC: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  18 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC