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SAFB antibody

CAT: 0710-FNab07578Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07578Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity) . Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity) . Can inhibit cell proliferation.
Synonyms
Scaffold attachment factor B1 (SAF-B, SAF-B1) |HSP27 estrogen response element-TATA box-binding protein (HSP27 ERE-TATA-binding protein) |SAFB|HAP|HET|SAFB1
Gene ID
6294
UniProt
Q15424
Host
Rabbit
Reactivity
Human
Immunogen
Scaffold attachment factor B
Target
SAFB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
150 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC

UniProtKB · Q15424

Scaffold attachment factor B1

SAFB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15424
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SAFB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SAF-B, SAF-B1
EC number
—
Processing
—
Secondary accessions
A0AV56, B7Z5B6, B7ZLP6, F5H0H3, O60406, Q59HH8
Protein keywords

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Technical term

Direct protein sequencingProteomics identificationReference proteome

Molecular function

DNA-bindingRepressorRNA-binding

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

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