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RXRA antibody

CAT: 0710-FNab07543Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07543Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
Synonyms
Retinoic acid receptor RXR-alpha|Nuclear receptor subfamily 2 group B member 1|Retinoid X receptor alpha|RXRA|NR2B1
Gene ID
6256
UniProt
P19793
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Retinoid X receptor, alpha
Target
RXRA
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB
Field of Research
Stem Cells, Signal Transduction, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:200-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
44 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
1A0
Tested Applications
ELISA, WB

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