RUNX2 antibody

RUNX2 antibody

• Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element(OCFRE)(By similarity). Inhibits KAT6B-dependent transcriptional activation.
• Synonyms: Runt-related transcription factor 2|Acute myeloid leukemia 3 protein|Core-binding factor subunit alpha-1 (CBF-alpha-1)|Oncogene AML-3|Osteoblast-specific transcription factor 2 (OSF-2)|Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A, PEBP2-alpha A)|SL3-3 enhancer factor 1 alpha A subunit|SL3/AKV core-binding factor alpha A subunit|RUNX2|AML3|CBFA1|OSF2|PEBP2A
• CAS Number: 9007-83-4
• Gene ID: 860
• UniProt: Q13950
• Host: Rabbit
• Reactivity: Human, Mouse
• Immunogen: runt-related transcription factor 2
• Target: RUNX2
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB
• Field of Research: Stem Cells, cancer, Neuroscience, Developmental biology
• Purification: Immunogen affinity purified
• Dilution: WB: 1:200-1:2000
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 50-60 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)