RUNX2 antibody

• Background:

  Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element(OCFRE)(By similarity). Inhibits KAT6B-dependent transcriptional activation.

• Synonyms:

  Runt-related transcription factor 2|Acute myeloid leukemia 3 protein|Core-binding factor subunit alpha-1 (CBF-alpha-1)|Oncogene AML-3|Osteoblast-specific transcription factor 2 (OSF-2)|Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A, PEBP2-alpha A)|SL3-3 enhancer factor 1 alpha A subunit|SL3/AKV core-binding factor alpha A subunit|RUNX2|AML3|CBFA1|OSF2|PEBP2A

• CAS Number:

  9007-83-4

• Gene ID:

  860

• UniProt:

  Q13950

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  runt-related transcription factor 2

• Target:

  RUNX2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Stem Cells, cancer, Neuroscience, Developmental biology

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  50-60 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)