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RUNX2 antibody

CAT: 0710-FNab07536Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07536Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1 (I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity) . Inhibits KAT6B-dependent transcriptional activation.
Synonyms
Runt-related transcription factor 2|Acute myeloid leukemia 3 protein|Core-binding factor subunit alpha-1 (CBF-alpha-1) |Oncogene AML-3|Osteoblast-specific transcription factor 2 (OSF-2) |Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A, PEBP2-alpha A) |SL3-3 enhancer factor 1 alpha A subunit|SL3/AKV core-binding factor alpha A subunit|RUNX2|AML3|CBFA1|OSF2|PEBP2A
Gene ID
860
UniProt
Q13950
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Runt-related transcription factor 2
Target
RUNX2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Stem Cells, cancer, Neuroscience, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50-60 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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