RPE65 antibody

CAT: 0710-FNab07401Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab07401Size:100 µg

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Background

Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.

Synonyms

Gene ID

6121

UniProt

Q16518

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Retinal pigment epithelium-specific protein 65kDa

Target

RPE65

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Field of Research

Neuroscience, Metabolism

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:5000

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

65 kDa, 61 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB

UniProtKB · Q16518

Retinoid isomerohydrolase

RPE65_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q16518
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: RPE65
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.1.1.64
Processing: —
Secondary accessions: A8K1L0, Q5T9U3

Protein keywords

PTM

AcetylationLipoproteinPalmitatePhosphoprotein

Cellular component

Cell membraneCytoplasmEndoplasmic reticulumMembraneMicrosome

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variantLeber congenital amaurosisRetinitis pigmentosa

Molecular function

HydrolaseIsomerase

Ligand

IronMetal-binding

Biological process

Lipid metabolismSensory transductionVision

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Alternative Products

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70R-19954	RPE65 antibody