ROCK2 antibody

CAT: 0710-FNab07378Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab07378Size:100 µg
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Background
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca (2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
Synonyms
Rho-associated protein kinase 2|Rho kinase 2|Rho-associated, coiled-coil-containing protein kinase 2|Rho-associated, coiled-coil-containing protein kinase II (ROCK-II) |p164 ROCK-2|ROCK2|KIAA0619
Gene ID
9475
UniProt
O75116
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Rho-associated, coiled-coil containing protein kinase 2
Target
ROCK2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:10000; IP: 1:200-1:2000; ; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
161 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP
Immunogen Sequence
1095-1388

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