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ROCK1 antibody

CAT: 0710-FNab07376Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07376Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
Synonyms
Rho-associated protein kinase 1|Renal carcinoma antigen NY-REN-35|Rho-associated, coiled-coil-containing protein kinase 1|Rho-associated, coiled-coil-containing protein kinase I (ROCK-I) |p160 ROCK-1 (p160ROCK) |ROCK1
Gene ID
6093
UniProt
Q13464
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Rho-associated, coiled-coil containing protein kinase 1
Target
ROCK1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
158 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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