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RNASEH1 antibody

CAT: 0710-FNab07327Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07327Size:100 µg
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Background
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183) . Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly (A) site and behind the elongating RNAp II (PubMed:21700224) .
Synonyms
Ribonuclease H1 (RNase H1) |Ribonuclease H type II|RNASEH1|RNH1
Gene ID
246243
UniProt
O60930
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ribonuclease H1
Target
RNASEH1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
32 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP
Immunogen Sequence
1-286aa, full length

UniProtKB · O60930

Ribonuclease H1

RNH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60930
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RNASEH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
RNase H1
EC number
3.1.26.4
Processing
—
Secondary accessions
B3KQU4, O60523, O60857, Q57Z93, Q5U0C1, Q6FHD4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cytoplasm

Disease

Disease variantPrimary mitochondrial diseaseProgressive external ophthalmoplegia

Molecular function

EndonucleaseHydrolaseNuclease

Ligand

MagnesiumMetal-binding