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RIPK2 antibody

CAT: 0710-FNab07314Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07314Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Synonyms
Receptor-interacting serine/threonine-protein kinase 2|CARD-containing interleukin-1 beta-converting enzyme-associated kinase (CARD-containing IL-1 beta ICE-kinase) |RIP-like-interacting CLARP kinase|Receptor-interacting protein 2 (RIP-2) |Tyrosine-protein kinase RIPK2|RIPK2|CARDIAK|RICK|RIP2
Gene ID
8767
UniProt
O43353
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Receptor-interacting serine-threonine kinase 2
Target
RIPK2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
46-55 kDa, 61-72 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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