RIPK3 antibody

• Background:

  Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

• Synonyms:

  Receptor-interacting serine/threonine-protein kinase 3|RIP-like protein kinase 3|Receptor-interacting protein 3 (RIP-3) |RIPK3|RIP3

• UniProt:

  Q9Y572

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Receptor-interacting serine-threonine kinase 3

• Target:

  RIPK3

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IP, WB,IHC

• Field of Research:

  Signal Transduction, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:100-1:400

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  57 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IP, WB, IHC