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RIPK3 antibody

CAT: 0710-FNab07312Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07312Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Synonyms
Receptor-interacting serine/threonine-protein kinase 3|RIP-like protein kinase 3|Receptor-interacting protein 3 (RIP-3) |RIPK3|RIP3
UniProt
Q9Y572
Host
Rabbit
Reactivity
Human
Immunogen
Receptor-interacting serine-threonine kinase 3
Target
RIPK3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IP, WB,IHC
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:100-1:400
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
57 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IP, WB, IHC

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