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RICTOR antibody

CAT: 0710-FNab07297Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07297Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Synonyms
Rapamycin-insensitive companion of mTOR|AVO3 homolog (hAVO3) |RICTOR|KIAA1999
Gene ID
253260
UniProt
Q6R327
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Rapamycin-insensitive companion of mTOR
Target
RICTOR
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:5000; IHC: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
192 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1-60AA

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