ATP6AP2 antibody

• Background:

  ATP6AP2, also named as ATP6IP2, CAPER, ELDF10, N14F, ATP6M8-9, Renin receptor and prorenin receptor, is believed to potentiate the renin–angiotensin system(RAS), conferring to prorenin, a likely pathological role at tissue level. The PRR has been identified in the microvascular endothelial cells of the retina, in which it seems to be involved in pathological neovascularization processes. The present study demonstrates for the first time that the PRR is expressed in human ATP6AP2 and suggests a molecular mechanism by which hypertension may exacerbate the pathology of dry AMD.

• Synonyms:

  Renin receptor|ATPase H(+)-transporting lysosomal accessory protein 2|ATPase H(+)-transporting lysosomal-interacting protein 2|ER-localized type I transmembrane adapter|Embryonic liver differentiation factor 10|N14F|Renin/prorenin receptor|Vacuolar ATP synthase membrane sector-associated protein M8-9 (ATP6M8-9, V-ATPase M8.9 subunit)|Renin receptor N-terminal fragment|Renin receptor C-terminal fragment|ATP6AP2|ATP6IP2|CAPER|ELDF10

• Gene ID:

  10159

• UniProt:

  O75787

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  ATPase, H+ transporting, lysosomal accessory protein 2

• Target:

  ATP6AP2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Signal Transduction, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:1000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  47 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

• CAS Number:

  9007-83-4