DDIT4-specific antibody

CAT: 0710-FNab07228Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab07228Size:100 µg
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Background
REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family.Its function:Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1) . Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity) . Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity) . Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.This antibody is specific to the REDD1.
Synonyms
DNA damage-inducible transcript 4 protein|HIF-1 responsive protein RTP801|Protein regulated in development and DNA damage response 1 (REDD-1) |DDIT4|REDD1|RTP801
Gene ID
54541
UniProt
Q9NX09
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
DNA-damage-inducible transcript 4
Target
DDIT4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IP, WB
Field of Research
Epigenetics, Immunology, Cardiovascular
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
35 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IP, WB

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