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RACGAP1 antibody

CAT: 0710-FNab07071Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07071Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.
Synonyms
Rac GTPase-activating protein 1|Male germ cell RacGap (MgcRacGAP) |Protein CYK4 homolog (CYK4, HsCYK-4) |RACGAP1|KIAA1478|MGCRACGAP
Gene ID
29127
UniProt
Q9H0H5
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Rac GTPase activating protein 1
Target
RACGAP1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IF
Field of Research
Signal Transduction, Developmental biology
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:20-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
71 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
1B5
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
400-632aa

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