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PRKG1 antibody

CAT: 0710-FNab06786Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06786Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II) . These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
Synonyms
CGMP-dependent protein kinase 1 (cGK 1, cGK1) |cGMP-dependent protein kinase I (cGKI) |PRKG1|PRKG1B|PRKGR1A|PRKGR1B
Gene ID
5592
UniProt
Q13976
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Protein kinase, cGMP-dependent, type I
Target
PRKG1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Neuroscience, Cardiovascular, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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