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PRKAG1 antibody

CAT: 0710-FNab10337Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10337Size:100 µg
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Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms
5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1, AMPK subunit gamma-1, AMPKg) |PRKAG1
Gene ID
5571
UniProt
P54619
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Target
PRKAG1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cardiovascular, Metabolism, Developmental biology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
35-40 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
164-321

UniProtKB · P54619

5'-AMP-activated protein kinase subunit gamma-1

AAKG1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P54619
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRKAG1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
AMPK gamma1, AMPK subunit gamma-1, AMPKg
EC number
—
Processing
—
Secondary accessions
B4DDT7, Q8N7V9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Domain

CBS domainRepeat

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolism

PTM

GlycoproteinPhosphoprotein

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