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TTR antibody

CAT: 0710-FNab06761Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06761Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transthyretin (TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition (amyloidosis) . Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR), hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) and carpal tunnel syndrome type 1 (CTS1) . In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors. (22103483)
Synonyms
Transthyretin|ATTR|Prealbumin|TBPA|TTR|PALB
Gene ID
7276
UniProt
P02766
Host
Mouse
Reactivity
Human
Immunogen
Transthyretin
Target
TTR
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC
Field of Research
Cancer, Immunology, Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
16 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
8E4
Tested Applications
ELISA, WB, IHC

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