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POLD1 antibody

CAT: 0710-FNab06606Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06606Size:100 µg
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Background
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.
Synonyms
DNA polymerase delta catalytic subunit|3'-5' exodeoxyribonuclease|DNA polymerase subunit delta p125|POLD1|POLD
Gene ID
5424
UniProt
P28340
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Polymerase (DNA directed), delta 1, catalytic subunit 125kDa
Target
POLD1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IF

UniProtKB · P28340

DNA polymerase delta catalytic subunit

DPOD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P28340
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POLD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.7.7
Processing
—
Secondary accessions
Q8NER3, Q96H98
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

4Fe-4SIronIron-sulfurMetal-bindingZinc

Disease

Disease variant

Biological process

DNA damageDNA excisionDNA repairDNA replication

Molecular function

DNA-bindingDNA-directed DNA polymeraseExonucleaseHydrolaseNucleaseNucleotidyltransferaseTransferase

PTM

Isopeptide bondMethylationUbl conjugation

Cellular component

Nucleus

Domain

Zinc-finger

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