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PIF1 antibody

CAT: 0710-FNab06436Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06436Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex(G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks(DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
CAS Number
9007-83-4
Synonyms
ATP-dependent DNA helicase PIF1|DNA repair and recombination helicase PIF1|PIF1/RRM3 DNA helicase-like protein|PIF1|C15orf20
Gene ID
80119
UniProt
Q9H611
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
PIF1 5'-to-3' DNA helicase homolog
Target
PIF1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
63-73 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

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