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PIK3CA antibody

CAT: 0710-FNab06417Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06417Size:100 µg
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Background
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns (4, 5) P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22.
Synonyms
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha) |Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha (PtdIns-3-kinase subunit p110-alpha, p110alpha) |Phosphoinositide 3-kinase alpha|Phosphoinositide-3-kinase catalytic alpha polypeptide|Serine/threonine protein kinase PIK3CA|PIK3CA
Gene ID
5290
UniProt
P42336
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Phosphoinositide-3-kinase, catalytic, alpha polypeptide
Target
PIK3CA
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
115-120 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
Peptide

UniProtKB · P42336

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

PK3CA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42336
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PIK3CA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha
EC number
2.7.1.137, 2.7.1.153
Processing
—
Secondary accessions
Q14CW1, Q99762
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

AngiogenesisLipid metabolismPhagocytosis

Ligand

ATP-bindingNucleotide-binding

Disease

Disease variantProto-oncogene

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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