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PELI2 antibody

CAT: 0710-FNab06304Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06304Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS-and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Synonyms
E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) |RING-type E3 ubiquitin transferase pellino homolog 2|PELI2
Gene ID
57161
UniProt
Q9HAT8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Pellino homolog 2 (Drosophila)
Target
PELI2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45-50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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