PDE9A antibody
CAT:
710-FNab06263
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PDE9A antibody
- Background: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP(PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart(PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein(Probable). In brain, involved in cognitive function, such as learning and long-term memory(By similarity).
- Synonyms: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A|PDE9A
- CAS Number: 9007-83-4
- Gene ID: 5152
- UniProt: O76083
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Immunogen: phosphodiesterase 9A
- Target: PDE9A
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IF, IHC
- Field of Research: Signal Transduction, Metabolism
- Purification: Immunogen affinity purified
- Dilution: IHC: 1:100-1:200; IF: 1:50-1:500
- Purity: ≥95% as determined by SDS-PAGE
- Form: Liquid
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)