PDE9A antibody

• Background:

  Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814) . Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991) . Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable) . In brain, involved in cognitive function, such as learning and long-term memory (By similarity) .

• Synonyms:

  High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A|PDE9A

• Gene ID:

  5152

• UniProt:

  O76083

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Phosphodiesterase 9A

• Target:

  PDE9A

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IF, IHC

• Field of Research:

  Signal Transduction, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  IHC: 1:100-1:200; IF: 1:50-1:500

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IF, IHC