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OMA1 antibody

CAT: 0710-FNab05991Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05991Size:100 µg
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Background
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.
Synonyms
Metalloendopeptidase OMA1, mitochondrial|Metalloprotease-related protein 1 (MPRP-1) |Overlapping with the m-AAA protease 1 homolog|OMA1|MPRP1
Gene ID
115209
UniProt
Q96E52
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
OMA1 homolog, zinc metallopeptidase
Target
OMA1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · Q96E52

Metalloendopeptidase OMA1, mitochondrial

OMA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96E52
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
OMA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.24.-
Processing
Precursor
Secondary accessions
D3DQ54, Q5T3G6, Q5T3G7, Q5T3G8, Q5T3G9, Q5T3H0, Q8NBB3
Protein keywords

Coding sequence diversity

Alternative splicing

PTM

Autocatalytic cleavageDisulfide bondZymogen

Molecular function

HydrolaseMetalloproteaseProtease

Ligand

Lipid-bindingMetal-bindingZinc

Cellular component

MembraneMitochondrionMitochondrion inner membrane

Technical term

Proteomics identificationReference proteome

Domain

Transit peptideTransmembraneTransmembrane helix

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