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OLR1 antibody

CAT: 0710-FNab05990Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05990Size:100 µg
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Background
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.
Synonyms
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) |C-type lectin domain family 8 member A|Lectin-like oxidized LDL receptor 1 (LOX-1, Lectin-like oxLDL receptor 1, hLOX-1) |Lectin-type oxidized LDL receptor 1|Oxidized low-density lipoprotein receptor 1, soluble form|OLR1|CLEC8A|LOX1
Gene ID
4973
UniProt
P78380
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Oxidized low density lipoprotein (lectin-like) receptor 1
Target
OLR1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Immunology, Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
26 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · P78380

Oxidized low-density lipoprotein receptor 1

OLR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P78380
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
OLR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Ox-LDL receptor 1
EC number
—
Processing
—
Secondary accessions
A8K7V9, B4DI48, G3V1I4, Q2PP00, Q7Z484
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionImmunityInflammatory response

Cellular component

Cell membraneMembraneSecreted

Domain

Coiled coilSignal-anchorTransmembraneTransmembrane helix

PTM

Disulfide bondGlycoproteinLipoproteinPalmitate

Ligand

Lectin

Molecular function

Receptor

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