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OAS2 antibody

CAT: 0710-FNab05950Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05950Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
Synonyms
2'-5'-oligoadenylate synthase 2 ((2-5') oligo (A) synthase 2, 2-5A synthase 2) |p69 OAS / p71 OAS (p69OAS / p71OAS) |OAS2
Gene ID
4939
UniProt
P29728
Host
Rabbit
Reactivity
Human
Immunogen
2'-5'-oligoadenylate synthetase 2, 69/71kDa
Target
OAS2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
66-71 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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