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OAS1 antibody

CAT: 0710-FNab05949Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05949Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
Synonyms
2'-5'-oligoadenylate synthase 1 ((2-5') oligo (A) synthase 1, 2-5A synthase 1) |E18/E16|p46/p42 OAS|OAS1|OIAS
Gene ID
4938
UniProt
P00973
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
2',5'-oligoadenylate synthetase 1, 40/46kDa
Target
OAS1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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