NTHL1 antibody

CAT: 0710-FNab05883Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab05883Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Synonyms

Endonuclease III-like protein 1 (hNTH1) |Bifunctional DNA N-glycosylase/DNA- (apurinic or apyrimidinic site) lyase (DNA glycosylase/AP lyase) |NTHL1|NTH1|OCTS3

Gene ID

4913

UniProt

P78549

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Nth endonuclease III-like 1 (E. coli)

Target

NTHL1

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IHC

Field of Research

Metabolism

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

34 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC

UniProtKB · P78549

Endonuclease III-like protein 1

NTH_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P78549
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NTHL1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: hNTH1
EC number: 3.2.2.-, 4.2.99.18
Processing: Precursor
Secondary accessions: Q1MVR1, Q99566, Q99794, Q9BPX2

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

4Fe-4SIronIron-sulfurMetal-binding

Coding sequence diversity

Alternative initiation

Biological process

DNA damageDNA repair

Molecular function

GlycosidaseHydrolaseLyase

Cellular component

MitochondrionNucleus

PTM

PhosphoproteinUbl conjugation

Domain

Transit peptide

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Alternative Products

Catalog	Name
OC-387-01	NTHL1 Antibody