NRG1 antibody

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537) . Binds to ERBB3 (PubMed:20682778) . Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778) . Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity) .

Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) |Neuregulin-1 Alternative names: Acetylcholine receptor-inducing activity (ARIA) |Breast cancer cell differentiation factor p45|Glial growth factor|Heregulin (HRG) |Neu differentiation factor|Sensory and motor neuron-derived factor|NRG1|GGF|HGL|HRGA|NDF|SMDF

3084

Q02297

Human, Mouse

Neuregulin 1

NRG1

ELISA, WB, IHC, IF, IP

Signal Transduction, Cardiovascular, Immunology, Developmental biology, Neuroscience

Immunogen affinity purified

WB: 1:500-1:1000; IHC: 1:50-1:200 IP:1:500-1:2000; IF: 1:50-1:500

≥95% as determined by SDS-PAGE

Liquid

55 kDa and 72 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

ELISA, WB, IHC, IF, IP