DBCO-PEG4-amine
CAT:
804-HY-130435-01
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DBCO-PEG4-amine
- CAS Number: 1840886-10-3
- UNSPSC Description: DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker)[1]. DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Target Antigen: ADC Linker; PROTAC Linkers
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/dbco-peg4-amine.html
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: O=C(NCCOCCOCCOCCOCCN)CCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O
- Molecular Weight: 523.62
- References & Citations: [1]Florinas S, et al. A Nanoparticle Platform To Evaluate Bioconjugation and Receptor-Mediated Cell Uptake Using Cross-Linked Polyion Complex Micelles Bearing Antibody Fragments. Biomacromolecules. 2016 May 9;17(5):1818-33.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, protect from light, stored under nitrogen)
- Clinical Information: No Development Reported