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NLRX1 antibody

CAT: 0710-FNab05759Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05759Size:100 µg
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Background
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase) -MAVS interaction (PubMed:18200010) . Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313) .
Synonyms
NLR family member X1|Caterpiller protein 11.3 (CLR11.3) |Nucleotide-binding oligomerization domain protein 5|Nucleotide-binding oligomerization domain protein 9|NLRX1|NOD5|NOD9
Gene ID
79671
UniProt
Q86UT6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
NLR family member X1
Target
NLRX1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC, IP
Field of Research
Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC, IP

UniProtKB · Q86UT6

NLR family member X1

NLRX1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86UT6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NLRX1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q96D51, Q9H724
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Host-virus interactionImmunityInnate immunity

Domain

Leucine-rich repeatRepeatTransit peptide

Cellular component

MembraneMitochondrionMitochondrion outer membrane

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