NFE2 antibody

CAT: 0710-FNab05692Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab05692Size:100 µg
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Background
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR) . This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Synonyms
Transcription factor NF-E2 45 kDa subunit|Leucine zipper protein NF-E2|Nuclear factor, erythroid-derived 2 45 kDa subunit|p45 NF-E2|NFE2
Gene ID
4778
UniProt
Q16621
Host
Rabbit
Reactivity
Human
Immunogen
Nuclear factor (erythroid-derived 2), 45kDa
Target
NFE2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP

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