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NEIL3 antibody

CAT: 0710-FNab05649Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05649Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) . In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA- (apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
Synonyms
Endonuclease 8-like 3|DNA glycosylase FPG2|DNA glycosylase/AP lyase Neil3|Endonuclease VIII-like 3|Nei-like protein 3|NEIL3
Gene ID
55247
UniProt
Q8TAT5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Nei endonuclease VIII-like 3 (E. coli)
Target
NEIL3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
62-68 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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