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NEIL1 antibody

CAT: 0710-FNab05648Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05648Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'-and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Synonyms
Endonuclease 8-like 1|DNA glycosylase/AP lyase Neil1|DNA- (apurinic or apyrimidinic site) lyase Neil1|Endonuclease VIII-like 1|FPG1|Nei homolog 1 (NEH1) |Nei-like protein 1|NEIL1
Gene ID
79661
UniProt
Q96FI4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Nei endonuclease VIII-like 1 (E. coli)
Target
NEIL1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
44 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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