NDEL1 antibody

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein-and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Nuclear distribution protein nudE-like 1 (Protein Nudel) |Mitosin-associated protein 1|NDEL1|EOPA|MITAP1|NUDEL

81565

Q9GZM8

Human, Mouse, Rat

NudE nuclear distribution gene E homolog (A. nidulans) -like 1

NDEL1

ELISA, WB, IP

Neuroscience, Cell Division and Proliferation, Developmental biology

Immunogen affinity purified

WB: 1:500-1:2000; IP: 1:200-1:2000

≥95% as determined by SDS-PAGE

Liquid

38-42 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)