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NDC80 antibody

CAT: 0710-FNab05599Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05599Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327) . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592) . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020) .
Synonyms
Kinetochore protein NDC80 homolog|Highly expressed in cancer protein|Kinetochore protein Hec1 (HsHec1) |Kinetochore-associated protein 2|Retinoblastoma-associated protein HEC|NDC80|HEC|HEC1|KNTC2
Gene ID
10403
UniProt
O14777
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
NDC80 homolog, kinetochore complex component
Target
NDC80
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Cell Division and Proliferation, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
76 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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