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MYL2 antibody

CAT: 0710-FNab05486Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05486Size:100 µg
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Background
Contractile protein that plays a role in heart development and function (By similarity) . Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) . During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity) .
Synonyms
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2, MLC-2v) |Cardiac myosin light chain 2|Myosin light chain 2, slow skeletal/ventricular muscle isoform (MLC-2s/v) |Ventricular myosin light chain 2|MYL2|MLC2
Gene ID
4633
UniProt
P10916
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Myosin, light chain 2, regulatory, cardiac, slow
Target
MYL2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Neuroscience, Immunology, Cardiovascular
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
18-20 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB
Immunogen Sequence
1-166aa

UniProtKB · P10916

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

MLRV_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10916
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MLC-2, MLC-2v
EC number
—
Processing
—
Secondary accessions
Q16123
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Disease

CardiomyopathyDisease variantMyofibrillar myopathy

Cellular component

Cytoplasm

PTM

MethylationPhosphoprotein

Molecular function

Motor proteinMuscle proteinMyosin

Domain

Repeat

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