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MYLK antibody

CAT: 0710-FNab05493Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05493Size:100 µg
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Background
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
Synonyms
Myosin light chain kinase, smooth muscle (MLCK, smMLCK) |Kinase-related protein (KRP) |Telokin|Myosin light chain kinase, smooth muscle, deglutamylated form|MYLK|MLCK|MLCK1|MYLK1
Gene ID
4638
UniProt
Q15746
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Myosin light chain kinase
Target
MYLK
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
140 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · Q15746

Myosin light chain kinase, smooth muscle

MYLK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15746
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYLK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MLCK, smMLCK
EC number
2.7.11.18
Processing
—
Secondary accessions
B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondPhosphoprotein

Molecular function

Actin-bindingCalmodulin-bindingKinaseSerine/threonine-protein kinaseTransferase

Coding sequence diversity

Alternative promoter usageAlternative splicing

Disease

Aortic aneurysmDisease variant

Ligand

ATP-bindingCalciumMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell projectionCytoplasmCytoskeleton

Domain

Immunoglobulin domainRepeat

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