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MYCN antibody

CAT: 0710-FNab05460Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05460Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms
N-myc proto-oncogene protein|Class E basic helix-loop-helix protein 37 (bHLHe37) |MYCN|BHLHE37|NMYC
Gene ID
4613
UniProt
P04198
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Target
MYCN
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Stem Cells, Cancer, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · P04198

N-myc proto-oncogene protein

MYCN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04198
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYCN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q53XS5, Q6LDT9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Disease

Disease variantProto-oncogene

Cellular component

Nucleus

PTM

Phosphoprotein

Biological process

TranscriptionTranscription regulation

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