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MUC1 antibody

CAT: 0710-FNab05427Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05427Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Synonyms
Mucin-1 (MUC-1) |Breast carcinoma-associated antigen DF3|Cancer antigen 15-3 (CA 15-3) |Carcinoma-associated mucin|Episialin|H23AG|Krebs von den Lungen-6 (KL-6) |PEMT|Peanut-reactive urinary mucin (PUM) |Polymorphic epithelial mucin (PEM) |Tumor-associated epithelial membrane antigen (EMA) |Tumor-associated mucin|Mucin-1 subunit alpha (MUC1-NT, MUC1-alpha) |Mucin-1 subunit beta (MUC1-beta) Alternative names: MUC1-CT|MUC1|PUM
Gene ID
4582
UniProt
P15941
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Mucin 1, cell surface associated
Target
MUC1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cancer, Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
122 kDa、23-30 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1182-1255aa

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