MUC4 antibody

• Background:

  May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

• Synonyms:

  Mucin-4 (MUC-4) |Ascites sialoglycoprotein (ASGP) |Pancreatic adenocarcinoma mucin|Testis mucin|Tracheobronchial mucin|Mucin-4 alpha chain Alternative names: Ascites sialoglycoprotein 1 (ASGP-1) |Mucin-4 beta chain Alternative names: Ascites sialoglycoprotein 2 (ASGP-2) |MUC4

• Gene ID:

  4585

• UniProt:

  Q99102

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Mucin 4, cell surface associated

• Target:

  MUC4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  235-250 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB