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MMS19 antibody

CAT: 0710-FNab05248Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05248Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
Synonyms
MMS19 nucleotide excision repair protein homolog (hMMS19) |MET18 homolog|MMS19-like protein|MMS19|MMS19L
Gene ID
64210
UniProt
Q96T76
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
MMS19 nucleotide excision repair homolog
Target
MMS19
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
103 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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