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MMACHC antibody

CAT: 0710-FNab05227Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05227Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalyzes the reductive dealkylation of cyanocobalamin to cob (II) alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810) . Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485) . Under anaerobic conditions cob (I) alamin is the first product; it is highly reactive and is converted to aquocob (II) alamin in the presence of oxygen (PubMed:19801555) . Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249) .
Synonyms
Cyanocobalamin reductase / alkylcobalamin dealkylase|Alkylcobalamin:glutathione S-alkyltransferase|CblC|Cyanocobalamin reductase (cyanide-eliminating) |Methylmalonic aciduria and homocystinuria type C protein (MMACHC) |MMACHC
Gene ID
25974
UniProt
Q9Y4U1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
Target
MMACHC
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
32 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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