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MLXIP antibody

CAT: 0710-FNab05223Size: 100 µgDry Ice: NoHazardous: No
CAT#: FNab05223Size: 100 µg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mlx-interacting protein (MLXIP), after forming heterodimers with MLX, can bind to and then activate transcription from CACGTG E boxes. The N terminus of MLXIP acts as a CRM1-dependent nuclear export signal and contribute to the cytoplasmic localization of the complex, and as a binding site for 13 protein. the C terminus contains a cytoplasmic localization signal and mediates protein-protein interaction of MONDOA and MLX. The complex play a role in transcriptional activation of glycolytic target genes and glucose-responsive gene regulation. This antibody could recognize isoform1 (~110kd) and isoform3 (~69kd) of MLXIP. A specific MLXIP of approximately 130 kDa was detected. It demonstrates that MLXIP associated specifically with Mlx in the cytoplasm (PMID: 11073985) .
Synonyms
MLX-interacting protein|Class E basic helix-loop-helix protein 36 (bHLHe36) |Transcriptional activator MondoA|MLXIP|BHLHE36|KIAA0867|MIR|MONDOA
Gene ID
22877
UniProt
Q9HAP2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
MLX interacting protein
Target
MLXIP
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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