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MINK1 antibody

CAT: 0710-FNab05191Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05191Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Synonyms
Misshapen-like kinase 1|GCK family kinase MiNK|MAPK/ERK kinase kinase kinase 6 (MEK kinase kinase 6, MEKKK 6) |Misshapen/NIK-related kinase|Mitogen-activated protein kinase kinase kinase kinase 6|MINK1|B55|MAP4K6|MINK|YSK2|ZC3
Gene ID
50488
UniProt
Q8N4C8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Misshapen-like kinase 1 (zebrafish)
Target
MINK1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
150 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1-304aa

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