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MGME1 antibody

CAT: 0710-FNab05168Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05168Size:100 µg
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Background
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC) -containing DNA in stem cells.
Synonyms
Mitochondrial genome maintenance exonuclease 1|MGME1|C20orf72|DDK1
Gene ID
92667
UniProt
Q9BQP7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Chromosome 20 open reading frame 72
Target
MGME1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
36-39 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · Q9BQP7

Mitochondrial genome maintenance exonuclease 1

MGME1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BQP7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MGME1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.-.-
Processing
—
Secondary accessions
B2RDG5, D3DW29, Q96SW3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Disease

Disease variantPrimary mitochondrial diseaseProgressive external ophthalmoplegia

Biological process

DNA damageDNA repair

Molecular function

ExonucleaseHydrolaseNuclease

Cellular component

Mitochondrion

PTM

Phosphoprotein

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