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METAP2 antibody

CAT: 0710-FNab05135Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05135Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) . The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Synonyms
Methionine aminopeptidase 2 (MAP 2, MetAP 2) |Initiation factor 2-associated 67 kDa glycoprotein (p67, p67eIF2) |Peptidase M|METAP2|MNPEP|P67EIF2
Gene ID
10988
UniProt
P50579
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Methionyl aminopeptidase 2
Target
METAP2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
67 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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