MAML1 antibody
CAT:
710-FNab04960
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MAML1 antibody
- Background: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
- Synonyms: Mastermind-like protein 1 (Mam-1)|MAML1|KIAA0200
- CAS Number: 9007-83-4
- Gene ID: 9794
- UniProt: Q92585
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Immunogen: mastermind-like 1(Drosophila)
- Target: MAML1
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, WB
- Field of Research: Metabolism, Developmental biology
- Purification: Immunogen affinity purified
- Dilution: WB: 1:500-1:2000
- Purity: ≥95% as determined by SDS-PAGE
- Form: Liquid
- Molecular Weight: 108-120 kDa
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)