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LRRC8D antibody

CAT: 0710-FNab04862Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04862Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E) ; channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658) . LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471) . Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309) .
Synonyms
Volume-regulated anion channel subunit LRRC8D|Leucine-rich repeat-containing protein 5|Leucine-rich repeat-containing protein 8D (HsLRRC8D) |LRRC8D|LRRC5
Gene ID
55144
UniProt
Q7L1W4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Leucine rich repeat containing 8 family, member D
Target
LRRC8D
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
98-120 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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